Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17024452 | 0.91 | LMNA (0.53) | LMNAPLA2G4BMAPTPOLBCYP2C9 | |
| SCHEMBL30737444 | 0.83 | LMNA (0.50) | LMNAMAPTPOLBCYP2C9HPGD | |
| SCHEMBL7421105 | 0.83 | CYP4F2 (0.52) | LMNAPLA2G4BMAPTPOLBCYP2C9 | |
| SCHEMBL6216172 | 0.82 | TSHR (0.49) | LMNAPLA2G4BMAPTPOLBCYP2C9 | |
| SCHEMBL29642028 | 0.82 | TSHR (0.49) | LMNAPLA2G4BMAPTPOLBCYP2C9 | |
| SCHEMBL7385040 | 0.82 | GAA (0.62) | LMNAMAPTPOLBHPGDALDH1A1 | |
| SCHEMBL7415227 | 0.81 | LMNA (0.44) | LMNAMAPTPOLBCYP2C9HPGD | |
| SCHEMBL7110156 | 0.81 | PPARA (0.55) | PLA2G4BNR1H2PSEN1PSEN2APH1B | |
| SCHEMBL7110609 | 0.81 | HSD17B10 (0.52) | LMNAMAPTCYP2C19PSEN1PSEN2 | |
| SCHEMBL2838476 | 0.81 | CYP3A4 (0.51) | LMNAMAPTPOLBCYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220773-B2 | Heterocylic amines used as antidiabetic or hyperglycemic agents | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-22 | — | — | US | disclosed |
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |