Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415278 | 1.00 | SIGMAR1 (0.42) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL7414839 | 0.96 | SIGMAR1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL7407659 | 0.96 | SIGMAR1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL7410376 | 0.96 | SIGMAR1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL7409859 | 0.96 | SIGMAR1 (0.43) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL7409858 | 0.96 | SIGMAR1 (0.43) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| Hydrochloric Acid SCHEMBL467325 | 0.95 | SIGMAR1 (0.42) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| Hydrochloric Acid SCHEMBL467326 | 0.95 | SIGMAR1 (0.42) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL7415431 | 0.92 | SIGMAR1 (0.47) | SIGMAR1HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL7078128 | 0.92 | SIGMAR1 (0.47) | SIGMAR1HTR2AHTR2CHTR2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734379-B1 | 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | PARKE DAVIS (FR) | 2001-03-07 | — | — | EP | claimed |
| US-6013656-A | PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; NERVOUSSYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-01-11 | — | — | US | claimed |
| EP-0734379-B1 | 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | PARKE DAVIS (FR) | 2001-03-07 | — | — | EP | disclosed |
| EP-0995436-A2 | Ligands for sigma receptors and their therapeutical applications | PARKE-DAVIS (FR) | 2000-04-26 | — | — | EP | disclosed |
| US-6013656-A | PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; NERVOUSSYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| US-5849760-A | 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1998-12-15 | — | — | US | disclosed |