Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474787 | 0.82 | TDP1 (0.54) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL676549 | 0.79 | TDP1 (0.50) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL1716610 | 0.77 | TDP1 (0.54) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL3700076 | 0.77 | TDP1 (0.54) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL9514386 | 0.75 | TSHR (0.39) | TDP1TET2GRIK1SLC1A3SLC1A2 | |
| SCHEMBL7412371 | 0.75 | TDP1 (0.39) | TDP1TET2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL9911940 | 0.74 | TDP1 (0.37) | TDP1TET2GRIK1GRIK2TET3 | |
| SCHEMBL48780 | 0.74 | CA2 (0.48) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL7541278 | 0.74 | CHRM1 (0.62) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL14574037 | 0.74 | CHRM1 (0.62) | TDP1CHRM1AKR1A1CHRM3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191150-B1 | METALLOPROTEASE INHIBITOR | GLAXO WELLCOME INC. | 2001-02-20 | — | — | US | disclosed |
| WO-2000012466-A1 | FORMAMIDE COMPOUNDS AS THERAPEUTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |