Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 7/20 | 0.56 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6418495 | 0.87 | NR4A2 (0.72) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL4780495 | 0.85 | NPC1 (0.66) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL30899481 | 0.85 | NPC1 (0.66) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL30697204 | 0.84 | NPC1 (0.64) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL2493105 | 0.84 | NPC1 (0.64) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL4164843 | 0.83 | NPC1 (0.63) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL6332786 | 0.82 | NPC1 (0.61) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL23551106 | 0.81 | NPC1 (0.60) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL3243814 | 0.81 | MAPT (0.67) | NPC1NR4A2ASH1LKIF11CREBBP | |
| SCHEMBL7416222 | 0.81 | NPC1 (0.64) | NPC1NR4A2ASH1LKIF11CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| CN-1187812-A | Indole derivatives as CGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-07-15 | — | — | CN | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |