Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416076 | 1.00 | ALOX5AP (0.40) | ALOX5APL3MBTL1DPP4GAAGFER | |
| SCHEMBL7424858 | 0.90 | L3MBTL1 (0.47) | ALOX5APL3MBTL1DPP4ALDH1A1NPC1 | |
| SCHEMBL7426692 | 0.90 | ALOX5AP (0.43) | ALOX5APL3MBTL1DPP4ALDH1A1NPC1 | |
| SCHEMBL7425177 | 0.87 | ALOX5AP (0.45) | ALOX5APL3MBTL1DPP4ALDH1A1MEN1 | |
| SCHEMBL7421847 | 0.87 | ALOX5AP (0.43) | ALOX5APL3MBTL1DPP4ALDH1A1KDM4E | |
| SCHEMBL687131 | 0.87 | ALOX5AP (0.47) | ALOX5APL3MBTL1DPP4ALDH1A1KDM4E | |
| SCHEMBL29611861 | 0.87 | ALOX5AP (0.47) | ALOX5APL3MBTL1DPP4ALDH1A1KDM4E | |
| SCHEMBL7424518 | 0.87 | ALOX5AP (0.43) | ALOX5APL3MBTL1DPP4ALDH1A1MAPT | |
| SCHEMBL7421179 | 0.86 | L3MBTL1 (0.43) | ALOX5APL3MBTL1DPP4ALDH1A1MEN1 | |
| SCHEMBL7427166 | 0.86 | ALOX5AP (0.39) | ALOX5APL3MBTL1DPP4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |