SCHEMBL7416178

SCHEMBL7416178

NNc1ncc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.55
ALDH1A1 P00352 6/20 0.54
TDP1 Q9NUW8 2/20 0.54
HTT P42858 2/20 0.46
MAPK1 P28482 2/20 0.46
CYP3A4 P08684 1/20 0.41
TXNRD1 Q16881 1/20 0.41
TXNRD3 Q86VQ6 1/20 0.41
TXNRD2 Q9NNW7 1/20 0.41
IDO1 P14902 1/20 0.41
GAA P10253 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
MAPT P10636 4/20 0.40
NPSR1 Q6W5P4 1/20 0.40
GPR35 Q9HC97 1/20 0.40
KDM4E B2RXH2 1/20 0.39
NPC1 O15118 1/20 0.39
MITF O75030 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30807120 0.82 ALDH1A1 (0.57) AHRALDH1A1TDP1HTTMAPK1
SCHEMBL6634074 0.82 ALDH1A1 (0.57) AHRALDH1A1TDP1HTTMAPK1
SCHEMBL23108354 0.82 IDO1 (0.44) AHRALDH1A1TDP1HTTMAPK1
SCHEMBL938628 0.81 POLB (0.38) AHRALDH1A1TDP1CYP3A4GAA
SCHEMBL13824874 0.81 SMN1; SMN2 (0.50) AHRALDH1A1TDP1CYP3A4MAPT
SCHEMBL16244085 0.81 ALDH1A1 (0.56) AHRALDH1A1TDP1HTTCYP3A4
SCHEMBL23925574 0.81 ALDH1A1 (0.43) AHRALDH1A1TDP1HTTMAPK1
SCHEMBL23580255 0.81 ALDH1A1 (0.47) AHRALDH1A1TDP1HTTMAPK1
SCHEMBL31646026 0.81 MEN1 (0.43) AHRALDH1A1TDP1HTTMAPK1
SCHEMBL3452960 0.79 AHR (0.59) AHRALDH1A1TDP1HTTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
US-5948793-A 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release ABBOTT LABORATORIES (US) 1999-09-07 US disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed
US-5914328-A CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS ABBOTT LABORATORIES (US) 1999-06-22 US disclosed
EP-0846114-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-06-10 EP disclosed
WO-1996040682-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1996-12-19 WO disclosed
US-5569763-A USEFUL AS ORGANIC NONLINEAR OPTICAL MATERIAL AND A HIGHLY SENSITIVE COLORING CHELATION AGENT KABUSHIKI KAISHA TOSHIBA (JP) 1996-10-29 US disclosed
US-4837308-A Process for the preparation of azo compounds BAYER AKTIENGESELLSCHAFT (DE) 1989-06-06 US disclosed
EP-0201892-B1 METHOD OF MAKING AZO COMPOUNDS BAYER AG (DE) 1989-03-08 EP disclosed
EP-0201892-A1 Method of making azo compounds BAYER AG (DE) 1986-11-20 EP disclosed