Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.74 |
| ▸ | RET | P07949 | 5/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.61 |
| ▸ | FLT3 | P36888 | 5/20 | 0.61 |
| ▸ | FLT1 | P17948 | 4/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.61 |
| ▸ | CSF1R | P07333 | 3/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.61 |
| ▸ | FLT4 | P35916 | 3/20 | 0.61 |
| ▸ | AURKA | O14965 | 3/20 | 0.61 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.61 |
| ▸ | STK3 | Q13188 | 3/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416755 | 1.00 | KDR (0.74) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL13052166 | 0.87 | KDR (0.80) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL5475085 | 0.85 | KDR (1.00) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL5475086 | 0.85 | KDR (1.00) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL6001621 | 0.84 | KDR (0.67) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL6001617 | 0.84 | KDR (0.67) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL5383570 | 0.80 | KDR (0.62) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL5469528 | 0.80 | KDR (1.00) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL5469533 | 0.80 | KDR (1.00) | KDRRETFGFR1FLT3FLT1 | |
| SCHEMBL6396129 | 0.80 | KDR (0.64) | KDRRETFGFR1FLT3FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769947-B1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 2001-05-02 | — | — | EP | claimed |
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | claimed |
| US-5792783-A | CAPABLE OF MODULATING TYROSINE KINASE SIGNAL TRANSDUCTION IN ORDER TO REGULATE, MODULATE AND/OR INHIBIT ABNORMAL CELL PROLIFERATION | SUGEN, INC. (US) | 1998-08-11 | — | — | US | claimed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | claimed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0769947-B1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 2001-05-02 | — | — | EP | disclosed |