Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.66 |
| ▸ | RET | P07949 | 5/20 | 0.66 |
| ▸ | FLT3 | P36888 | 5/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.66 |
| ▸ | FLT1 | P17948 | 4/20 | 0.66 |
| ▸ | AURKA | O14965 | 3/20 | 0.66 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.66 |
| ▸ | STK3 | Q13188 | 3/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.66 |
| ▸ | CSF1R | P07333 | 3/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.66 |
| ▸ | FLT4 | P35916 | 3/20 | 0.66 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | PLK4 | O00444 | 2/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.66 |
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475086 | 0.89 | KDR (1.00) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL5469528 | 0.89 | KDR (1.00) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL5469533 | 0.89 | KDR (1.00) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL5475085 | 0.89 | KDR (1.00) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL6001617 | 0.88 | KDR (0.67) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL6001621 | 0.88 | KDR (0.67) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL13101870 | 0.88 | KDR (0.70) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL7416754 | 0.87 | KDR (0.74) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL7416755 | 0.87 | KDR (0.74) | KDRPDGFRBFGFR1RETFLT3 | |
| SCHEMBL6000845 | 0.86 | PDGFRB (1.00) | KDRPDGFRBFGFR1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, HTT, PARK7 | KDR 3586/4885PDGFRB 2159/4885FGFR1 4427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.