Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733057 | 0.89 | TSHR (0.58) | TSHRPOLBCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1837988 | 0.88 | TDP1 (0.53) | TSHRPOLBCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7007840 | 0.88 | TDP1 (0.53) | TSHRPOLBCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1099625 | 0.85 | TSHR (0.52) | TSHRPOLBCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7011029 | 0.81 | NAMPT (0.57) | TSHRPOLBCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3597587 | 0.80 | TSHR (0.60) | TSHRPOLBCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL24990193 | 0.80 | CA2 (0.59) | CYP1A2ALDH1A1CYP3A4HTTSMN1; SMN2 | |
| Acetic Acid SCHEMBL28216269 | 0.78 | MAPT (0.56) | TSHRPOLBCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL6562898 | 0.77 | KMT2A (0.45) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL7534037 | 0.77 | CYP1A2 (0.50) | TSHRPOLBCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | claimed |