Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26619266 | 0.87 | KDM4E (0.47) | KMT2AALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL6219929 | 0.81 | ALDH1A1 (0.56) | KMT2AALDH1A1KDM4EHPGDNUDT1 | |
| SCHEMBL14829330 | 0.80 | ALDH1A1 (0.52) | KMT2AALDH1A1KDM4EHPGDNUDT1 | |
| SCHEMBL754622 | 0.80 | ALDH1A1 (0.55) | KMT2AALDH1A1KDM4EHPGDNUDT1 | |
| SCHEMBL23674982 | 0.78 | ALDH1A1 (0.53) | KMT2AALDH1A1KDM4EHPGDNUDT1 | |
| SCHEMBL16386608 | 0.78 | ALDH1A1 (0.57) | KMT2AALDH1A1KDM4EHPGDNUDT1 | |
| SCHEMBL2222793 | 0.77 | CA12 (0.42) | KMT2AALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL11296630 | 0.76 | TSHR (0.63) | KMT2AALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL1156163 | 0.75 | KMT2A (0.58) | KMT2AALDH1A1KDM4EHPGDNUDT1 | |
| SCHEMBL25068659 | 0.75 | KDM4E (0.47) | KMT2AALDH1A1KDM4EHPGDNUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649432-B1 | FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS | ZENECA LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| US-5532366-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-07-02 | — | — | US | disclosed |
| EP-0649432-A1 | FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994001455-A1 | FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1994-01-20 | — | — | WO | disclosed |