SCHEMBL7417030

SCHEMBL7417030

O=C(N[C@@H](Cc1ccccc1)c1ncc[nH]1)OCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 3/20 0.53
CTRB1 P17538 2/20 0.51
SSTR1 P30872 1/20 0.50
AAK1 Q2M2I8 3/20 0.48
CTSL P07711 4/20 0.47
CTSB P07858 3/20 0.47
CTSS P25774 3/20 0.47
CTSK P43235 1/20 0.46
ATM Q13315 1/20 0.45
CYP3A4 P08684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7451931 1.00 TACR1 (0.53) TACR1CTRB1SSTR1AAK1CTSL
SCHEMBL3346730 1.00 TACR1 (0.53) TACR1CTRB1SSTR1AAK1CTSL
SCHEMBL7421358 0.89 FPR2 (0.51) TACR1CTRB1SSTR1AAK1CTSL
SCHEMBL14923445 0.88 AAK1 (0.61) AAK1CTSLCTSBCTSSCTSK
SCHEMBL7466643 0.88 AAK1 (0.61) AAK1CTSLCTSBCTSSCTSK
SCHEMBL7466082 0.88 AAK1 (0.61) AAK1CTSLCTSBCTSSCTSK
SCHEMBL7418294 0.87 FPR2 (0.53) SSTR1AAK1CTSLCTSBCTSS
Trifluoroacetic Acid SCHEMBL8540672 0.85 AAK1 (0.55) AAK1CTSLCTSBCTSSCTSK
SCHEMBL391686 0.84 CYP1A2 (0.47) CYP3A4
SCHEMBL27724873 0.84 CYP1A2 (0.47) CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874842-B1 MERCAPTOALKYLPEPTIDYL COMPOUNDS HAVING AN IMIDAZOLE SUBSTITUENT AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES (MMP) AND/OR TUMOUR NECROSIS FACTOR (TNF) DARWIN DISCOVERY LTD (GB) 2002-04-10 EP disclosed
US-6048841-A ENZYME INHIBITOR; ANTAGONIST AGAINST TUMOR NECROSIS FACTOR DARWIN DISCOVERY, LTD. (GB) 2000-04-11 US disclosed
EP-0874842-A1 MERCAPTOALKYLPEPTIDYL COMPOUNDS HAVING AN IMIDAZOLE SUBSTITUENT AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES (MMP) AND/OR TUMOUR NECROSIS FACTOR (TNF) Darwin Discovery Limited (GB) 1998-11-04 EP disclosed
US-5733882-A Retroviral protease inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1998-03-31 US disclosed
WO-1997019075-A1 MERCAPTOALKYLPEPTIDYL COMPOUNDS HAVING AN IMIDAZOLE SUBSTITUENT AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES (MMP) AND/OR TUMOUR NECROSIS FACTOR (TNF) DARWIN DISCOVERY LIMITED (GB) 1997-05-29 WO disclosed
WO-1993002057-A1 RETROVIRAL PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1993-02-04 WO disclosed