Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.61 |
| ▸ | PDE4A | P27815 | 8/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420808 | 0.90 | PDE4D (0.66) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7415300 | 0.88 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7348827 | 0.87 | PDE4D (0.52) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7355475 | 0.81 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL2954077 | 0.78 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL2961023 | 0.78 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7350382 | 0.78 | PDE4D (0.56) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL15270511 | 0.77 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL5038816 | 0.76 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL5038747 | 0.76 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993015044-A1 | N-BENZYLOXAMIC ACID, OXAMATE, AND OXAMIDE DERIVATIVES AND THEIR USE AS TNF AND PDE IV INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-08-05 | — | — | WO | claimed |
| WO-1993015044-A1 | N-BENZYLOXAMIC ACID, OXAMATE, AND OXAMIDE DERIVATIVES AND THEIR USE AS TNF AND PDE IV INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-08-05 | — | — | WO | disclosed |