Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657171 | 0.84 | SMN1; SMN2 (0.55) | TRPM8RIPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13696513 | 0.80 | TAAR1 (0.46) | TRPM8RIPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL11466844 | 0.79 | MEN1 (0.51) | TRPM8RIPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL14376819 | 0.77 | MAPT (0.51) | RIPK1ALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL27305404 | 0.77 | SMN1; SMN2 (0.49) | RIPK1ALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL1304013 | 0.76 | — | — | |
| SCHEMBL29955953 | 0.74 | SMN1; SMN2 (0.50) | RIPK1ALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL15720861 | 0.74 | MAPT (0.48) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28582399 | 0.74 | HPGD (0.53) | TRPM8RIPK1ALDH1A1SMN1; SMN2HPGD | |
| Ethane SCHEMBL8092722 | 0.74 | TAAR1 (0.56) | TRPM8RIPK1ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718643-B2 | Multimodal anion exchange matrices | CYTIVA BIOPROCESS R&D AB (SE) | 2023-08-08 | — | — | US | disclosed |
| US-11718643-B2 | Multimodal anion exchange matrices | CYTIVA BIOPROCESS R&D AB (SE) | 2023-08-08 | — | — | US | disclosed |
| US-10815269-B2 | Multimodal anion exchange matrices | GE HEALTHCARE BIOPROCESS R&D AB (SE) | 2020-10-27 | — | — | US | disclosed |
| US-20190023735-A1 | Multimodal Anion Exchange Matrices | GE HEALTHCARE BIOPROCESS R&D AB (SE) | 2019-01-24 | — | — | US | disclosed |
| US-20150299248-A1 | Multimodal Anion Exchange Matrices | GE Healtchare Bio-Sciences AB (SE) | 2015-10-22 | — | — | US | disclosed |
| US-20150299248-A1 | Multimodal Anion Exchange Matrices | GE Healtchare Bio-Sciences AB (SE) | 2015-10-22 | — | — | US | disclosed |
| CN-1247593-C | Thiepino [3, 2-b ] dihydropyridines and related compositions and methods | ORTHO MCNEIL PHARM INC (US) | 2006-03-29 | — | — | CN | disclosed |
| CN-1522257-A | Thiepino[3,2-b]dihydropyridines and related compositions and methods | ����-������ҩƷ��˾ | 2004-08-18 | — | — | CN | disclosed |
| EP-1265903-A1 | THIEPINO[3,2-B]DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6420383-B1 | CALCIUM CHANNEL BLOCKERS, HYPERSENSITIVITY, ALLERGY, ASTHMA, BRONCHOSPASM, DYSMENORRHEA, ESOPHAGEAL SPASM, GLAUCOMA, PREMATURE LABOR, URINARY TRACT DISORDERS, GASTROINTESTINAL MOTILITY DISORDERS AND CARDIOVASCULAR DISORDERS. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-07-16 | — | — | US | disclosed |
| WO-2001070748-A1 | THIEPINO [3,2-b] DIHYDROPYRIDINES AND RELATED COMPOSITIONS AND METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| CN-1038587-C | 1,4-Dihydropyridines, process for preparation thereof and their application as medicinal products | DELAGRANGE LAB (ES) | 1998-06-03 | — | — | CN | disclosed |
| EP-0302980-B1 | 1,4-DIHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | LABORATORIOS DELAGRANGE S.A. (ES) | 1991-03-13 | — | — | EP | disclosed |
| US-4952592-A | HYPOTENSIVE, CARDIOTONIC AGENTS | INSTITUTO DE INVESTIGACION Y DESARROLLO QUIMICOBIOLOGICO S.A. (ES) | 1990-08-28 | — | — | US | disclosed |
| CN-1031531-A | 1,4-dihydropyridine its preparation method and be used for the purposes of medicine | DELAGRANGE LAB (ES) | 1989-03-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815269-B2 | Multimodal anion exchange matrices | H1-3, H1-4, IGF2R | TRPM8 1460/4885RIPK1 3550/4885ALDH1A1 2226/4885 |
| US-11718643-B2 | Multimodal anion exchange matrices | H1-3, H1-4, IGF2R | TRPM8 1460/4885RIPK1 3550/4885ALDH1A1 2226/4885 |
| US-20150299248-A1 | Multimodal Anion Exchange Matrices | H1-3, H1-4, IGF2R | TRPM8 1460/4885RIPK1 3550/4885ALDH1A1 2226/4885 |
| US-20190023735-A1 | Multimodal Anion Exchange Matrices | H1-3, H1-4, IGF2R | TRPM8 1460/4885RIPK1 3550/4885ALDH1A1 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.