Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 19/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 19/20 | 0.68 |
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386282 | 0.83 | PDE3B (0.72) | PDE3BPDE3APDE2AP2RY12 | |
| SCHEMBL7382885 | 0.83 | PDE3B (0.72) | PDE3BPDE3APDE2AP2RY12 | |
| SCHEMBL7377041 | 0.82 | PDE3B (0.76) | PDE3BPDE3APDE2AP2RY12 | |
| Hydrochloric Acid SCHEMBL7385661 | 0.82 | PDE3B (0.70) | PDE3BPDE3APDE2AP2RY12 | |
| SCHEMBL7383419 | 0.82 | PDE3B (0.70) | PDE3BPDE3APDE2AP2RY12 | |
| SCHEMBL2463204 | 0.81 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL7377131 | 0.78 | PDE3B (0.65) | PDE3BPDE3A | |
| SCHEMBL7384334 | 0.77 | PDE3B (0.64) | PDE3BPDE3A | |
| SCHEMBL7377905 | 0.77 | PDE3B (0.64) | PDE3BPDE3A | |
| SCHEMBL9763113 | 0.75 | PDE3B (0.60) | PDE3BPDE3APDE2AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | disclosed |