Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.64 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383915 | 0.85 | PDE3B (0.58) | PDE3BPDE3AMEN1KMT2AMAPT | |
| SCHEMBL7383419 | 0.84 | PDE3B (0.70) | PDE3BPDE3A | |
| SCHEMBL7375384 | 0.83 | PDE3B (0.55) | PDE3BPDE3AKDM4EMEN1HPGD | |
| SCHEMBL7382710 | 0.83 | PDE3B (0.55) | PDE3BPDE3AKDM4EALDH1A1MEN1 | |
| SCHEMBL7386282 | 0.82 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7382885 | 0.80 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7377905 | 0.80 | PDE3B (0.64) | PDE3BPDE3AKDM4EALDH1A1MEN1 | |
| SCHEMBL7377041 | 0.79 | PDE3B (0.76) | PDE3BPDE3AADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL7385661 | 0.79 | PDE3B (0.70) | PDE3BPDE3A | |
| SCHEMBL23242456 | 0.79 | ALDH1A1 (0.47) | XDHADORA2AADORA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | claimed |
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | disclosed |