Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.76 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419331 | 0.88 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7424183 | 0.87 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7421227 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL22500809 | 0.86 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7425456 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL13350317 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7418696 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL24437313 | 0.82 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL30985365 | 0.82 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7420597 | 0.82 | PDE4B (0.69) | PDE4APDE4BPDE4CPDE4DCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036596-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036596-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |