Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 6/20 | 0.43 |
| ▸ | FLT3 | P36888 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | STK25 | O00506 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740260 | 0.90 | AURKA (0.47) | IMPDH2KITFLT3HDAC1CACNA1H | |
| SCHEMBL4633211 | 0.83 | KIT (0.48) | KITFLT3HDAC1CACNA1HSTK25 | |
| SCHEMBL741121 | 0.80 | KIT (0.50) | KITFLT3AURKAABL1BCR | |
| SCHEMBL742867 | 0.79 | ABL1 (0.58) | KITFLT3HDAC1AURKAKDM4E | |
| SCHEMBL742153 | 0.79 | ABL1 (0.60) | KITFLT3HDAC1AURKAKDM4E | |
| SCHEMBL739473 | 0.79 | ABL1 (0.61) | KITFLT3HDAC1AURKAKDM4E | |
| SCHEMBL741946 | 0.79 | ABL1 (0.61) | KITFLT3HDAC1AURKAKDM4E | |
| SCHEMBL741622 | 0.78 | RAB9A (0.41) | FLT3AURKAKDM4EPOLBABL1 | |
| SCHEMBL742121 | 0.78 | AURKA (0.62) | KITFLT3AURKAABL1BCR | |
| SCHEMBL742527 | 0.78 | AURKA (0.52) | KITFLT3AURKAABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |