Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1226277 | 0.88 | MAPT (0.42) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL2979173 | 0.77 | MAPT (0.41) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL4058588 | 0.77 | MAPT (0.41) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Imidazole SCHEMBL8825076 | 0.76 | ALDH1A1 (0.34) | MAPTGAA | |
| SCHEMBL7407772 | 0.74 | MAPT (0.35) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL7026732 | 0.74 | MAPT (0.41) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL27600468 | 0.74 | MAPT (0.37) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL27427681 | 0.74 | SMN1; SMN2 (0.42) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL15865155 | 0.74 | MAPT (0.37) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| SCHEMBL4915107 | 0.74 | GAA (0.37) | MAPTGAARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880122-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-09 | — | — | US | claimed |
| US-5880122-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-09 | — | — | US | disclosed |