Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | DDX3X | O00571 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5852144 | 0.86 | LPAR1 (0.71) | MEN1KMT2AGAADDX3XMAPT | |
| SCHEMBL3460669 | 0.84 | MAPT (0.60) | MEN1KMT2AGAADDX3XMAPT | |
| SCHEMBL17978458 | 0.82 | LPAR1 (0.59) | MEN1KMT2AGAADDX3XMAPT | |
| SCHEMBL4675624 | 0.81 | MEN1 (0.59) | MEN1KMT2AGAADDX3XMAPT | |
| SCHEMBL14222078 | 0.81 | MEN1 (0.59) | MEN1KMT2AGAADDX3XMAPT | |
| SCHEMBL5595187 | 0.81 | CA12 (0.60) | MEN1KMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL16592515 | 0.81 | GAA (0.59) | MEN1KMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL4674769 | 0.80 | MEN1 (0.57) | MEN1KMT2AGAADDX3XMAPT | |
| SCHEMBL14500970 | 0.79 | MEN1 (0.56) | MEN1KMT2AGAADDX3XMAPT | |
| SCHEMBL5701006 | 0.79 | ITGA4 (0.61) | MEN1KMT2AGAADDX3XMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |