Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12093506 | 0.92 | SYK (0.49) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL2685379 | 0.91 | SYK (0.50) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL15716592 | 0.89 | SYK (0.55) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL2748437 | 0.88 | SYK (0.49) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL16490057 | 0.87 | SYK (0.49) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL25346745 | 0.86 | CCR6 (0.52) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL25970217 | 0.86 | SYK (0.53) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL17948 | 0.85 | IDO1 (0.47) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL14023844 | 0.85 | SYK (0.45) | SYKIDO1CCR6PAX8CKS1B | |
| SCHEMBL17545677 | 0.85 | SYK (0.49) | SYKIDO1CCR6PAX8CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610165-A | N-acylpiperidine tachykinin antagonists | MERCK & CO., INC. (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1995022525-A1 | N-ACYLPIPERIDINE TACHYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| US-5344830-A | Anitinflammatory, cardiovascular, analgesic, central nervous system | MERCK & CO., INC. (US) | 1994-09-06 | — | — | US | disclosed |
| WO-1994013646-A1 | N,N-DIACYLPIPERAZINE TACHYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1994-06-23 | — | — | WO | disclosed |