Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | SDCBP | O00560 | 3/20 | 0.42 |
| ▸ | SDC2 | P34741 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419479 | 1.00 | NPSR1 (0.45) | NPSR1SMN1; SMN2SDCBPSDC2ALDH1A1 | |
| SCHEMBL29434612 | 0.84 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL31240964 | 0.83 | NPSR1 (0.44) | NPSR1SMN1; SMN2SDCBPSDC2ALDH1A1 | |
| SCHEMBL24687077 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPT | |
| SCHEMBL15756824 | 0.81 | NPSR1 (0.43) | NPSR1SMN1; SMN2SDCBPSDC2ALDH1A1 | |
| SCHEMBL30569794 | 0.81 | PSMB5 (0.49) | NPSR1SMN1; SMN2SDCBPSDC2ALDH1A1 | |
| SCHEMBL15756817 | 0.81 | NPSR1 (0.43) | NPSR1SMN1; SMN2SDCBPSDC2ALDH1A1 | |
| SCHEMBL29967328 | 0.80 | NPSR1 (0.42) | NPSR1SMN1; SMN2SDCBPSDC2ALDH1A1 | |
| SCHEMBL29349612 | 0.80 | ALDH1A1 (0.42) | NPSR1SMN1; SMN2SDCBPSDC2ALDH1A1 | |
| SCHEMBL23922525 | 0.80 | ALDH1A1 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256677-A | Enzyme inhibitor for treating acquired immune deficiency syndrome | ABBOTT LABORATORIES (US) | 1993-10-26 | — | — | US | disclosed |
| WO-1992017176-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-10-15 | — | — | WO | disclosed |
| US-5151438-A | Enzyme inhibitors for treatment of aids | ABBOTT LABORATORIES (US) | 1992-09-29 | — | — | US | disclosed |