Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.54 |
| ▸ | HTR3B | O95264 | 3/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.54 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416784 | 0.99 | HTR3A (0.55) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7416260 | 0.89 | HTR3A (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7423010 | 0.84 | HTR3A (0.45) | HTR3A | |
| SCHEMBL7419706 | 0.83 | HTR3A (0.64) | HTR3AKCNH2 | |
| SCHEMBL7413463 | 0.83 | HTR3A (0.64) | HTR3AKCNH2 | |
| SCHEMBL7413930 | 0.83 | HTR3A (0.64) | HTR3AKCNH2 | |
| SCHEMBL7416644 | 0.83 | HTR3A (0.64) | HTR3AKCNH2 | |
| SCHEMBL7409421 | 0.82 | HTR3A (0.65) | HTR3AKCNH2 | |
| SCHEMBL7417154 | 0.80 | HTR3A (0.65) | HTR3AKCNH2 | |
| SCHEMBL7415240 | 0.79 | HTR3A (0.48) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991016888-A1 | SPIRO[BENZOFURANCYCLOALKANE]CARBOXAMIDES AS 5HT3 ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-11-14 | — | — | WO | claimed |
| WO-1991016888-A1 | SPIRO[BENZOFURANCYCLOALKANE]CARBOXAMIDES AS 5HT3 ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-11-14 | — | — | WO | disclosed |