Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.58 |
| ▸ | MMP9 | P14780 | 17/20 | 0.58 |
| ▸ | MMP1 | P03956 | 14/20 | 0.58 |
| ▸ | ADAM10 | O14672 | 7/20 | 0.58 |
| ▸ | MMP14 | P50281 | 6/20 | 0.58 |
| ▸ | MMP2 | P08253 | 6/20 | 0.58 |
| ▸ | MMP13 | P45452 | 11/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | ADAM8 | P78325 | 4/20 | 0.53 |
| ▸ | MMP12 | P39900 | 3/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.51 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939484 | 1.00 | ADAM17 (0.58) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3940966 | 0.97 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL6864328 | 0.97 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3940506 | 0.91 | ADAM17 (0.67) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL7414380 | 0.91 | ADAM17 (0.67) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3940926 | 0.91 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3944138 | 0.91 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL7423135 | 0.91 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3940147 | 0.90 | ADAM17 (0.58) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3944287 | 0.89 | ADAM17 (0.68) | ADAM17MMP9MMP1ADAM10MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | claimed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | claimed |
| WO-2002083112-A2 | METHOD FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE | WYETH HOLDINGS CORPORATION (US) | 2002-10-24 | — | — | WO | disclosed |