Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422125 | 0.91 | AGTR1 (0.39) | AGTR1AGTR2FOLH1ALDH1A1CNR2 | |
| SCHEMBL7470080 | 0.89 | S1PR3 (0.41) | AGTR1AGTR2HPGDKDM4ECNR2 | |
| SCHEMBL7421489 | 0.89 | SLC22A12 (0.43) | AGTR1AGTR2ALDH1A1HPGDKDM4E | |
| SCHEMBL7427161 | 0.88 | AGTR1 (0.38) | AGTR1AGTR2ALDH1A1HPGDKDM4E | |
| SCHEMBL7425450 | 0.88 | AGTR1 (0.46) | AGTR1AGTR2ALDH1A1HPGDFABP4 | |
| SCHEMBL7427533 | 0.88 | ALOX5AP (0.46) | ALDH1A1SLC22A12 | |
| SCHEMBL7424763 | 0.87 | AGTR1 (0.39) | AGTR1AGTR2ALDH1A1HPGDKDM4E | |
| SCHEMBL7707842 | 0.87 | ALOX5AP (0.45) | ALDH1A1SLC22A12 | |
| SCHEMBL7422911 | 0.86 | AGTR1 (0.48) | AGTR1AGTR2FEN1FABP4PLA2G2A | |
| SCHEMBL7422028 | 0.85 | TSHR (0.45) | AGTR1AGTR2ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| CN-1187812-A | Indole derivatives as CGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-07-15 | — | — | CN | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |