Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 6/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2788224 | 0.92 | CA1 (0.41) | CA1CA2CA9EGFRLPL | |
| SCHEMBL10345253 | 0.86 | CA1 (0.40) | CA1CA2CA9GRM2EGFR | |
| SCHEMBL10324272 | 0.86 | CA1 (0.40) | CA1CA2CA9GRM2EGFR | |
| SCHEMBL10324273 | 0.86 | CA1 (0.40) | CA1CA2CA9GRM2EGFR | |
| SCHEMBL741453 | 0.85 | CA1 (0.36) | CA1CA2CA9EGFRLPL | |
| SCHEMBL3708691 | 0.85 | CA1 (0.39) | CA1CA2CA9EGFRLPL | |
| SCHEMBL171262 | 0.85 | LPL (0.39) | CA1CA2CA9EGFRMAPK1 | |
| SCHEMBL1826305 | 0.81 | PDE3B (0.45) | GRM2MAPK1MAPK3LPLLIPG | |
| SCHEMBL18339584 | 0.81 | PRKCQ (0.37) | GRM2LPLLIPGHIF1AOPRL1 | |
| SCHEMBL2816021 | 0.78 | CA1 (0.47) | CA1CA2CA9MAPK1LPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085577-B2 | 7-aryl-1,2,4-triazolo[4,3-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2015-07-21 | — | — | US | disclosed |
| US-9085577-B2 | 7-aryl-1,2,4-triazolo[4,3-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2015-07-21 | — | — | US | disclosed |
| US-9085577-B2 | 7-aryl-1,2,4-triazolo[4,3-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2015-07-21 | — | — | US | disclosed |
| US-8906939-B2 | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives | Janssen Pharmaceuticals, Inc. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906939-B2 | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives | Janssen Pharmaceuticals, Inc. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906939-B2 | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives | Janssen Pharmaceuticals, Inc. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8796311-B2 | — | — | 2014-08-05 | — | — | US | disclosed |
| US-8796311-B2 | — | — | 2014-08-05 | — | — | US | disclosed |
| US-8796311-B2 | — | — | 2014-08-05 | — | — | US | disclosed |
| US-20140200208-A1 | 7-ARYL-1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ADDEX PHARMA, S.A. (CH) | 2014-07-17 | — | — | US | disclosed |
| EP-2134708-B1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO MCNEIL JANSSEN PHARM (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2134708-B1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO MCNEIL JANSSEN PHARM (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010130423-A1 | 7-ARYL-1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010130423-A1 | 7-ARYL-1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20100087487-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | Ortho-McNeil Janssen Pharmaceuticals Inc. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087487-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | Ortho-McNeil Janssen Pharmaceuticals Inc. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087487-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | Ortho-McNeil Janssen Pharmaceuticals Inc. (US) | 2010-04-08 | — | — | US | disclosed |
| EP-2134708-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008107481-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107481-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200208-A1 | 7-ARYL-1,2,4-TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM1, GRIA2 | CA1 3955/4885CA2 1366/4885CA9 4837/4885 |
| US-20100087487-A1 | 3-CYANO-4-(4-TETRAHYDROPYRAN-PHENYL)-PYRIDIN-2-ONE DERIVATIVES | GRM2, GRM3, GRIK2 | CA1 2828/4885CA2 522/4885CA9 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.