Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 2/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740292 | 0.89 | AURKA (0.55) | AURKAABL1BCRIMPDH2USP36 | |
| SCHEMBL740809 | 0.85 | AURKA (0.52) | AURKAABL1BCRIMPDH2USP36 | |
| SCHEMBL4632531 | 0.84 | AURKA (0.37) | AURKA | |
| SCHEMBL739086 | 0.84 | AURKA (0.50) | AURKAABL1BCRIMPDH2TACR3 | |
| SCHEMBL738866 | 0.84 | AURKA (0.53) | AURKAABL1BCRIMPDH2ROCK2 | |
| SCHEMBL741311 | 0.84 | AURKA (0.53) | AURKAABL1BCRIMPDH2USP36 | |
| SCHEMBL742901 | 0.84 | ABL1 (0.49) | AURKAABL1BCRTACR3PHGDH | |
| SCHEMBL741044 | 0.83 | AURKA (0.51) | AURKAABL1BCRIMPDH2USP36 | |
| SCHEMBL739779 | 0.83 | AURKA (0.52) | AURKAABL1BCRROCK2ROCK1 | |
| SCHEMBL740955 | 0.83 | CDK7 (0.48) | AURKAABL1BCRIMPDH2USP36 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |