Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.68 |
| ▸ | PDE4A | P27815 | 17/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.68 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352724 | 0.84 | PDE4B (0.73) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7363664 | 0.81 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| Piclamilast SCHEMBL26573 | 0.81 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7417912 | 0.80 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7335911 | 0.80 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7359780 | 0.80 | PDE4B (0.76) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.79 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7439590 | 0.79 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7474577 | 0.78 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890987 | 0.78 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | claimed |
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |