Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 7/20 | 0.47 |
| ▸ | CTSL | P07711 | 5/20 | 0.47 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15289516 | 0.82 | LMNA (0.57) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| SCHEMBL6463767 | 0.80 | LMNA (0.48) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| SCHEMBL2520296 | 0.78 | SMN1; SMN2 (0.63) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| Benzyl Phenethylcarbamate SCHEMBL27338403 | 0.77 | LMNA (0.61) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| SCHEMBL13055383 | 0.77 | LMNA (0.80) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| SCHEMBL2391033 | 0.76 | LMNA (0.65) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| SCHEMBL8026594 | 0.76 | SMN1; SMN2 (0.65) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| SCHEMBL9190671 | 0.75 | LMNA (0.58) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| SCHEMBL11631912 | 0.75 | LMNA (0.58) | LMNASMN1; SMN2HTTTGM2KEAP1 | |
| Water SCHEMBL8101580 | 0.74 | LMNA (0.71) | LMNASMN1; SMN2HTTTGM2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |