Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648574 | 0.80 | ERN1 (0.44) | ALDH1A1CYP3A4MAPTPKMHTT | |
| SCHEMBL2132590 | 0.80 | TDP1 (0.44) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL29617721 | 0.80 | TDP1 (0.44) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL631164 | 0.78 | ALDH1A1 (0.63) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL18964368 | 0.78 | ALDH1A1 (0.63) | TDP1ALDH1A1CYP3A4MAPTMAPK1 | |
| SCHEMBL18496986 | 0.77 | ATM (0.48) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL30155391 | 0.77 | CYP1A2 (0.52) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL993946 | 0.77 | CYP1A2 (0.52) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL103118 | 0.77 | TTR (0.50) | TDP1ALDH1A1MAPTMAPK1HIF1A | |
| SCHEMBL16972863 | 0.77 | TDP1 (0.47) | TDP1ATMALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250186425-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | FLARE THERAPEUTICS INC. | 2025-06-12 | — | — | US | disclosed |
| EP-4490147-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | Flare Therapeutics Inc. (US) | 2025-01-15 | — | — | EP | disclosed |
| CN-118984823-A | PPARG inverse agonists and uses thereof | 弗拉雷治疗公司 | 2024-11-19 | — | — | CN | disclosed |
| WO-2023172845-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | FLARE THERAPEUTICS INC. (US) | 2023-09-14 | — | — | WO | disclosed |
| US-5547991-A | NMDA antagonism method | MERRELL PHARMACEUTICALS INC. (US) | 1996-08-20 | — | — | US | disclosed |
| US-5484814-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5470870-A | New class of excitatory amino acid antagonist for epilepsy, anxiety or stroke | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0501378-B1 | NMDA Antagonists | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5360814-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0501378-A1 | NMDA Antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250186425-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | PPARG, PPARA, PPARD | TDP1 3127/4885ATM 2659/4885ALDH1A1 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.