Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.70 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.70 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.67 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.67 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.67 |
| ▸ | GABRP | O00591 | 4/20 | 0.63 |
| ▸ | GABRD | O14764 | 4/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.63 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.63 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.63 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.63 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.63 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.63 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.63 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.63 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.63 |
| ▸ | GABRE | P78334 | 4/20 | 0.63 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.63 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.63 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420797 | 1.00 | GRIN1 (0.70) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL7354723 | 1.00 | GRIN1 (0.70) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL18346701 | 0.91 | GRIN1 (0.68) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL18346685 | 0.91 | GRIN1 (0.68) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL22453518 | 0.90 | GRIN1 (0.69) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL22989687 | 0.89 | GRIN1 (0.71) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL12028989 | 0.89 | GRIN1 (0.71) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL22989665 | 0.89 | GRIN1 (0.71) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL12028991 | 0.89 | GRIN1 (0.71) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL12028987 | 0.89 | GRIN1 (0.71) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591733-A | TREATMENT OF ANXIETY, STRESS, INSOMNIA, SEIZURES, STEROIDS, ACTIVE AT GAMMA-AMINOBUTYRIC ACID RECEPTORS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 1997-01-07 | — | — | US | claimed |
| WO-1993003732-A1 | GABA RECEPTOR MODULATORS | COCENSYS, INC. (US) | 1993-03-04 | — | — | WO | claimed |
| EP-0554436-B1 | GABA RECEPTOR MODULATORS | EURO CELTIQUE SA (LU) | 2000-07-05 | — | — | EP | disclosed |
| US-5591733-A | TREATMENT OF ANXIETY, STRESS, INSOMNIA, SEIZURES, STEROIDS, ACTIVE AT GAMMA-AMINOBUTYRIC ACID RECEPTORS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 1997-01-07 | — | — | US | disclosed |
| US-5232917-A | Tranquillizers; antianxiolytic agents; sedatives; antidepressants; anticonvulsants; neurotransmitters | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1993003732-A1 | GABA RECEPTOR MODULATORS | COCENSYS, INC. (US) | 1993-03-04 | — | — | WO | disclosed |