Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420901 | 0.85 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CMKNK1 | |
| SCHEMBL7427953 | 0.84 | PDE4D (0.44) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7427352 | 0.82 | PDE4D (0.46) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7426462 | 0.79 | MEN1 (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7420906 | 0.79 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CMKNK1 | |
| SCHEMBL7421486 | 0.77 | PDE4D (0.44) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6883325 | 0.76 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CMKNK1 | |
| Hydrochloric Acid SCHEMBL8203396 | 0.73 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CMKNK1 | |
| SCHEMBL27483513 | 0.73 | CYP2A6 (0.50) | MKNK1MKNK2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7427950 | 0.69 | PDE4D (0.46) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780478-A | Tetra-substituted phenyl derivatives | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |