SCHEMBL7420959

SCHEMBL7420959

COCc1c(C(=O)C(C)C)c2ccc(C(N)=O)cc2n1Cc1ccccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 3/20 0.47
L3MBTL1 Q9Y468 1/20 0.41
DPP4 P27487 1/20 0.41
F2RL3 Q96RI0 2/20 0.39
ALDH1A1 P00352 2/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
TP53 P04637 4/20 0.38
RXFP1 Q9HBX9 2/20 0.38
TNF P01375 1/20 0.38
PLA2G2A P14555 2/20 0.38
MAPT P10636 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7472045 0.91 ALOX5AP (0.46) ALOX5APL3MBTL1DPP4F2RL3ALDH1A1
SCHEMBL7418990 0.90 MAPT (0.44) ALOX5APL3MBTL1DPP4F2RL3ALDH1A1
SCHEMBL7420321 0.90 ALOX5AP (0.48) ALOX5APL3MBTL1DPP4ALDH1A1MEN1
SCHEMBL7426945 0.89 ALOX5AP (0.54) ALOX5APL3MBTL1DPP4ALDH1A1MEN1
SCHEMBL687131 0.88 ALOX5AP (0.47) ALOX5APL3MBTL1DPP4ALDH1A1MEN1
SCHEMBL7422326 0.86 L3MBTL1 (0.51) ALOX5APL3MBTL1DPP4ALDH1A1MEN1
SCHEMBL7468891 0.82 MAPT (0.44) ALOX5APL3MBTL1DPP4F2RL3ALDH1A1
SCHEMBL7421044 0.82 ALOX5AP (0.45) ALOX5APL3MBTL1DPP4ALDH1A1MEN1
SCHEMBL7471120 0.82 ALOX5AP (0.44) ALOX5APL3MBTL1DPP4ALDH1A1MEN1
SCHEMBL7427098 0.82 ALOX5AP (0.44) ALOX5APL3MBTL1DPP4ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0820441-B1 INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS FUJISAWA PHARMACEUTICAL CO (JP) 2002-06-26 EP disclosed
US-6358992-B1 Method of inhibiting neoplastic cells with indole derivatives CELL PATHWAYS, INC. 2002-03-19 US disclosed
US-6069156-A Indole derivatives as cGMP-PDE inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-05-30 US disclosed
EP-0820441-A1 INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-01-28 EP disclosed
WO-1996032379-A1 INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-17 WO disclosed