Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715790 | 0.84 | MAPT (0.47) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7417406 | 0.83 | ALDH1A1 (0.70) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4036462 | 0.82 | SMN1; SMN2 (0.49) | KDM4EALDH1A1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7845711 | 0.82 | MAPT (0.50) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7422213 | 0.81 | ALDH1A1 (0.54) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7416266 | 0.81 | ALDH1A1 (0.54) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3148140 | 0.81 | ALDH1A1 (0.49) | MAPTKDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL3662801 | 0.81 | CA12 (0.47) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2104354 | 0.81 | ALDH1A1 (0.66) | MAPTKDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL8717644 | 0.80 | ALDH1A1 (0.50) | MAPTLMNAKDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885205-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-0885205-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5780480-A | THROMBOLYTIC AGENTS, ANTICOAGULANTS | MERCK & CO., INC. (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1997031910-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-09-04 | — | — | WO | disclosed |