Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 11/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419400 | 0.91 | KCNA5 (0.48) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL8015046 | 0.87 | KCNA5 (0.56) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL7351711 | 0.86 | KCNA5 (0.53) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL7423956 | 0.85 | KCNA5 (0.49) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL7422208 | 0.82 | KCNA5 (0.46) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL7423616 | 0.82 | KCNA5 (0.46) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL7350978 | 0.76 | KCNA5 (0.54) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL7342866 | 0.71 | CNR1 (0.60) | KEAP1NFE2L2KCNA5CNR1CNR2 | |
| SCHEMBL7355017 | 0.71 | KEAP1 (0.48) | KEAP1NFE2L2KCNA5MMP9MMP1 | |
| SCHEMBL7359705 | 0.70 | KEAP1 (0.56) | KEAP1NFE2L2KCNA5MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873312-B1 | ALPHA-SUBSTITUTED ARYLSULPHONAMIDO HYDROXAMIC ACIDS AS TNF-ALPHA AND MATRIX METALLOPROTEINASE INHIBITORS | NOVARTIS AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| EP-0873312-A1 | ALPHA-SUBSTITUTED ARYLSULPHONAMIDO HYDROXAMIC ACIDS AS TNF-ALPHA AND MATRIX METALLOPROTEINASE INHIBITORS | Novartis AG (CH) | 1998-10-28 | — | — | EP | disclosed |
| US-5770624-A | INHIBITORS OF TUMOR NECROSIS FACTOR ALPHA AND MATRIX DEGRADING METALLOPROTEINEASE ACTIVITY | NOVARTIS CORP. (US) | 1998-06-23 | — | — | US | disclosed |
| WO-1997022587-A1 | ALPHA-SUBSTITUTED ARYLSULPHONAMIDO HYDROXAMIC ACIDS AS TNF-ALPHA AND MATRIX METALLOPROTEINASE INHIBITORS | NOVARTIS AG (CH) | 1997-06-26 | — | — | WO | disclosed |