Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinapril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 16/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinapril SCHEMBL4359590 | 1.00 | ACE (0.98) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL153436 | 1.00 | ACE (0.98) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL6548496 | 1.00 | ACE (0.98) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL29381792 | 1.00 | ACE (0.98) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL29357257 | 1.00 | ACE (0.98) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL41404 | 1.00 | ACE (0.98) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL678447 | 0.99 | ACE (1.00) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL11294979 | 0.99 | ACE (1.00) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL9094436 | 0.99 | ACE (1.00) | ACEABCB11PDE3ALMNASMN1; SMN2 | |
| Quinapril SCHEMBL19361887 | 0.99 | ACE (1.00) | ACEABCB11PDE3ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028728-A1 | USE OF QUINAPRIL FOR TREATING MYOCARDIAL ISCHEMIA AND ANGINA | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-0992495-A1 | PROCESS FOR OBTAINING QUINAPRYL HYDROCHLORIDE AND SOLVATES USEFUL FOR ISOLATING AND PURIFYING QUINAPRYL HYDROCHLORIDE | ESTEVE QUIMICA, S.A. (ES) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999022736-A1 | USE OF QUINAPRIL FOR TREATING MYOCARDIAL ISCHEMIA AND ANGINA | WARNER-LAMBERT COMPANY (US) | 1999-05-14 | — | — | WO | disclosed |
| EP-0285992-B1 | CRYSTALLINE QUINAPRIL AND A PROCESS FOR PRODUCING THE SAME | WARNER-LAMBERT COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| EP-0285992-A1 | Crystalline quinapril and a process for producing the same | WARNER-LAMBERT COMPANY (US) | 1988-10-12 | — | — | EP | disclosed |
| US-4761479-A | HYPOTENSIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1988-08-02 | — | — | US | disclosed |