Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763299 | 0.90 | HRH1 (0.40) | HRH1CYP2D6KCNH2USP2POLB | |
| SCHEMBL741718 | 0.89 | HRH1 (0.46) | HRH1CYP2D6KCNH2USP2POLB | |
| SCHEMBL739901 | 0.86 | HRH1 (0.46) | HRH1CYP2D6KCNH2USP2POLB | |
| SCHEMBL742306 | 0.85 | HRH1 (0.41) | HRH1CYP2D6KCNH2USP2POLB | |
| SCHEMBL742584 | 0.81 | USP2 (0.53) | HRH1CYP2D6KCNH2USP2POLB | |
| SCHEMBL742498 | 0.80 | HRH1 (0.49) | HRH1CYP2D6KCNH2USP2POLB | |
| SCHEMBL740708 | 0.80 | HRH1 (0.39) | HRH1CYP2D6KCNH2CHRM1ALDH1A1 | |
| SCHEMBL739252 | 0.80 | KCNH2 (0.41) | HRH1CYP2D6KCNH2CHRM1ALDH1A1 | |
| SCHEMBL762816 | 0.79 | HRH1 (0.42) | HRH1CYP2D6KCNH2USP2POLB | |
| SCHEMBL740857 | 0.79 | KCNH2 (0.39) | HRH1CYP2D6KCNH2CHRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |