Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.50 |
| ▸ | HRH1 | P35367 | 9/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742781 | 0.86 | KCNH2 (0.48) | USP2POLBKCNH2HRH1CYP2D6 | |
| SCHEMBL742278 | 0.81 | HRH1 (0.43) | USP2POLBKCNH2HRH1CYP2D6 | |
| SCHEMBL739857 | 0.80 | HRH1 (0.57) | USP2POLBKCNH2HRH1CYP2D6 | |
| SCHEMBL763593 | 0.78 | HRH1 (0.63) | USP2POLBKCNH2HRH1CYP2D6 | |
| SCHEMBL743157 | 0.78 | HRH1 (0.63) | USP2POLBKCNH2HRH1CYP2D6 | |
| SCHEMBL2636396 | 0.75 | HTR2B (0.66) | USP2POLBKCNH2HRH1CYP2D6 | |
| SCHEMBL16528509 | 0.71 | SMN1; SMN2 (0.54) | HRH1MAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL18991537 | 0.70 | USP2 (1.00) | USP2POLBKCNH2HRH1CYP2D6 | |
| SCHEMBL23581880 | 0.70 | HSD17B10 (0.53) | MAPK1SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL2883397 | 0.70 | HSD17B10 (0.53) | MAPK1SMN1; SMN2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |