Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001444 | 0.83 | GSK3B (0.51) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL6001442 | 0.83 | GSK3B (0.51) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL7423015 | 0.70 | KDR (0.60) | ALKGSK3BTLK2MAPTPTK2B | |
| SCHEMBL5728617 | 0.70 | FLT3 (0.63) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL5728618 | 0.70 | FLT3 (0.63) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL6001525 | 0.70 | GSK3B (0.62) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL6001522 | 0.70 | GSK3B (0.62) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL578229 | 0.69 | CDK5 (0.58) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL578228 | 0.69 | CDK5 (0.58) | ALKGSK3BTLK2MAPTCDK5 | |
| SCHEMBL6000982 | 0.69 | GSK3B (0.61) | ALKGSK3BTLK2MAPTCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883116-A | ANTITUMOR AGENTS AND ENZYME INHIBITORS | SUGEN, INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |