Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 8/20 | 0.43 |
| ▸ | NOS1 | P29475 | 8/20 | 0.43 |
| ▸ | NOS3 | P29474 | 6/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL9667416 | 1.00 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL6433292 | 0.96 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL6433284 | 0.96 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL1898345 | 0.94 | OTC (0.49) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL6946785 | 0.94 | OTC (0.49) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL288808 | 0.94 | OTC (0.49) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL5698936 | 0.94 | OTC (0.49) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL263652 | 0.94 | OTC (0.49) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL20946267 | 0.94 | OTC (0.49) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL288809 | 0.94 | OTC (0.49) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002048179-A1 | GAMMA-KETOACID DIPEPTIDE DERIVATIVES AS INHIBITORS OF CASPASE-3 | MERCK FROSST CANADA & CO. (CA) | 2002-06-20 | — | — | WO | disclosed |
| WO-1999050229-A1 | FATTY ACID ANALOGS AND PRODRUGS | G.D. SEARLE & CO. (US) | 1999-10-07 | — | — | WO | disclosed |
| US-5759788-A | High affinity L-proline transporter polypeptides; antibodies and immunoassays specific for them | EMORY UNIVERSITY (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0739195-A4 | SKIN TANNING COMPOSITIONS | ESTEE LAUDER INC (US) | 1997-02-26 | — | — | EP | disclosed |
| EP-0739195-A1 | SKIN TANNING COMPOSITIONS | ESTEE LAUDER INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| US-5503824-A | FIRST COMPONENT CONTAINING DIHYDROXYACETONE, SECOND COMPONENT CONTAINING AMINO-SUBSTITUTED SILICONE OR POLYAZIRIDINE WHICH REACTS WITH FIRST TO INCREASE RATE AND DEGREE OF TAN IMPARTED TO HUMAN SKIN | ESTEE LAUDER INC. | 1996-04-02 | — | — | US | disclosed |
| WO-1995015742-A1 | SKIN TANNING COMPOSITIONS | ESTEE LAUDER INC. (US) | 1995-06-15 | — | — | WO | disclosed |
| EP-0506923-A1 | A COLLAGEN BINDING PROTEIN AS WELL AS ITS PREPARATION. | ALFA LAVAL AGRI INT (SE) | 1992-10-07 | — | — | EP | disclosed |
| WO-1992007002-A1 | A COLLAGEN BINDING PROTEIN AS WELL AS ITS PREPARATION | ALFA-LAVAL AGRI INTERNATIONAL AKTIEBOLAG (SE) | 1992-04-30 | — | — | WO | disclosed |