Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | ACP1 | P24666 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421668 | 0.90 | PDPK1 (0.54) | PDPK1DYRK1AACP1LRRK2ALDH1A1 | |
| SCHEMBL5869988 | 0.80 | PAX8 (0.54) | PDPK1DYRK1AACP1LRRK2ALDH1A1 | |
| SCHEMBL5869979 | 0.80 | PAX8 (0.54) | PDPK1DYRK1AACP1LRRK2ALDH1A1 | |
| SCHEMBL5869910 | 0.80 | PAX8 (0.54) | PDPK1DYRK1AACP1LRRK2ALDH1A1 | |
| SCHEMBL5870315 | 0.79 | PDPK1 (0.55) | PDPK1DYRK1AACP1LRRK2ALDH1A1 | |
| SCHEMBL5870537 | 0.79 | PDPK1 (0.55) | PDPK1DYRK1AACP1LRRK2ALDH1A1 | |
| SCHEMBL7424266 | 0.79 | DYRK1A (0.53) | DYRK1AACP1ALDH1A1KDM4EPTPN1 | |
| SCHEMBL5870526 | 0.79 | PDPK1 (0.55) | PDPK1DYRK1AACP1LRRK2ALDH1A1 | |
| SCHEMBL7427256 | 0.78 | DYRK1A (0.54) | DYRK1AACP1ALDH1A1KDM4EPTPN1 | |
| SCHEMBL7421229 | 0.78 | DYRK1A (0.54) | DYRK1AACP1ALDH1A1KDM4EPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |