Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.97 |
| ▸ | GAA | P10253 | 5/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.97 |
| ▸ | POLB | P06746 | 3/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.97 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | S100B | P04271 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29805515 | 0.98 | KDM4E (1.00) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL19291349 | 0.85 | KDM4E (0.72) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL15776926 | 0.85 | KDM4E (0.78) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL4433893 | 0.85 | KDM4E (0.77) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL23292230 | 0.85 | GAA (0.77) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL11819784 | 0.84 | NPC1 (0.77) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL29978999 | 0.83 | KDM4E (0.74) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL11818379 | 0.83 | NPC1 (0.75) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL10733821 | 0.83 | NPC1 (0.75) | KDM4EGAAHSD17B10POLBTDP1 | |
| SCHEMBL13856584 | 0.83 | KDM4E (1.00) | KDM4EGAAHSD17B10POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5210266-A | Analgesic enkephalinase inhibitors | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| US-5179125-A | Analgesics | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| EP-0318859-A2 | N-substituted mercaptopropanamide derivatives | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-06-07 | — | — | EP | disclosed |