Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28213543 | 0.78 | CCNB2 (0.57) | KDRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL5728269 | 0.77 | KDR (0.59) | KDRRAF1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5728271 | 0.77 | KDR (0.59) | KDRRAF1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL14448901 | 0.77 | KDR (0.59) | KDRRAF1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL7534633 | 0.75 | GSK3B (0.47) | ALDH1A1MAPTSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL7420796 | 0.75 | SMN1; SMN2 (0.49) | KDRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL1444136 | 0.74 | MAPT (0.54) | KDRALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1444503 | 0.74 | MAPT (0.54) | KDRALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL7421881 | 0.72 | EGFR (0.51) | ALDH1A1MAPTSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL3749858 | 0.72 | RAF1 (0.72) | KDRRAF1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |