Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12257138 | 0.84 | KDM4E (0.46) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL11773551 | 0.83 | KDM4E (0.51) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL11776420 | 0.83 | KDM4E (0.51) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL2533444 | 0.81 | ACMSD (0.61) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL9244562 | 0.80 | KDM4E (0.49) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL9249778 | 0.80 | AKR1C4 (0.53) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL7955284 | 0.80 | ACMSD (0.59) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL11775718 | 0.76 | KDM4E (0.46) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL9250275 | 0.76 | PTPN1 (0.55) | KDM4EMEN1MAPTKMT2AACMSD | |
| SCHEMBL9247116 | 0.76 | KDM4E (0.46) | KDM4EMEN1MAPTKMT2AACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| WO-1992009284-A1 | 2,6-METHANO-2H-1-BENZOXOCINCARBOXAMIDES AS 5-HT3-ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-06-11 | — | — | WO | disclosed |