Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAD | Q92934 | 5/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 0.35 |
| ▸ | RGS12 | O14924 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437286 | 0.76 | ABCG2 (0.41) | BADABCG2ALDH1A1CYP1A2KDM4E | |
| SCHEMBL7426502 | 0.71 | ABCG2 (0.35) | BADABCG2ALDH1A1CYP1A2KDM4E | |
| SCHEMBL2411016 | 0.71 | CYP1A2 (0.32) | CYP1A2 | |
| SCHEMBL7432722 | 0.70 | ABCG2 (0.38) | ABCG2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL30400843 | 0.69 | BAD (0.49) | BADABCG2ALDH1A1CYP1A2KDM4E | |
| SCHEMBL403982 | 0.69 | BAD (0.49) | BADABCG2ALDH1A1CYP1A2KDM4E | |
| SCHEMBL2412656 | 0.67 | HPRT1 (0.33) | — | |
| SCHEMBL2884931 | 0.66 | ABCG2 (0.52) | ABCG2SMN1; SMN2LMNACYP3A4PKM | |
| SCHEMBL9871797 | 0.66 | BAD (0.53) | BADABCG2ALDH1A1CYP1A2KDM4E | |
| SCHEMBL4894 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283310-B1 | N-BENZHYDRYL-SUBSTITUTED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-5028610-A | Calcium Channel Blockers | SANKYO COMPANY LIMITED (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0283310-A1 | N-Benzhydryl-substituted heterocyclic derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-09-21 | — | — | EP | disclosed |