Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418536 | 0.99 | SLC6A4 (0.66) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| SCHEMBL7418255 | 0.88 | SIGMAR1 (0.71) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| SCHEMBL10551886 | 0.87 | SIGMAR1 (0.73) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| SCHEMBL10576449 | 0.86 | SLC6A4 (0.64) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| Hydrochloric Acid SCHEMBL10576163 | 0.85 | SLC6A4 (0.65) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| SCHEMBL8907432 | 0.84 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| SCHEMBL8907716 | 0.84 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| SCHEMBL10571285 | 0.83 | SIGMAR1 (0.68) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| SCHEMBL7413526 | 0.82 | SLC6A4 (0.63) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 | |
| Hydrochloric Acid SCHEMBL10635083 | 0.82 | SLC6A4 (0.77) | SLC6A4SLC6A3SLC6A2LMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276035-A | Central nervous system disorders; Parkinson's disease; antidepressant and dopaminergic agent | NOVO NORDISK A/S (DK) | 1994-01-04 | — | — | US | disclosed |
| EP-0541617-A1 | 1,4-DISUBSTITUTED PIPERAZINES. | NOVO NORDISK AS (DK) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992001679-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1992-02-06 | — | — | WO | disclosed |