Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10635083 | 0.83 | SLC6A4 (0.77) | SIGMAR1SLC6A4SLC6A3SLC6A2MEN1 | |
| SCHEMBL10635609 | 0.82 | SLC6A4 (0.88) | SIGMAR1SLC6A4SLC6A3SLC6A2MEN1 | |
| Hydrochloric Acid SCHEMBL11077810 | 0.81 | SLC6A4 (0.86) | SIGMAR1SLC6A4SLC6A3SLC6A2MEN1 | |
| SCHEMBL7419078 | 0.78 | SIGMAR1 (0.65) | SIGMAR1SLC6A4SLC6A3SLC6A2MEN1 | |
| SCHEMBL10631998 | 0.78 | SLC6A4 (0.90) | SLC6A4SLC6A3 | |
| SCHEMBL1578007 | 0.78 | SLC6A4 (0.59) | SIGMAR1SLC6A4SLC6A3SLC6A2MEN1 | |
| SCHEMBL10551886 | 0.78 | SIGMAR1 (0.73) | SIGMAR1SLC6A4SLC6A3SLC6A2MEN1 | |
| Hydrochloric Acid SCHEMBL10632291 | 0.77 | SLC6A4 (0.88) | SLC6A4SLC6A3 | |
| SCHEMBL7720831 | 0.76 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL10552245 | 0.76 | SLC6A4 (0.78) | SIGMAR1SLC6A4SLC6A3SLC6A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0541617-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 1997-06-04 | — | — | EP | disclosed |
| US-5276035-A | Central nervous system disorders; Parkinson's disease; antidepressant and dopaminergic agent | NOVO NORDISK A/S (DK) | 1994-01-04 | — | — | US | disclosed |
| EP-0541617-A1 | 1,4-DISUBSTITUTED PIPERAZINES. | NOVO NORDISK AS (DK) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992001679-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1992-02-06 | — | — | WO | disclosed |