Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714950 | 0.84 | HTR2A (0.70) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4644851 | 0.83 | HTR2A (0.56) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13617885 | 0.83 | HTR2A (0.53) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1119050 | 0.81 | HTR2A (0.53) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4641611 | 0.81 | HTR2A (0.54) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14296886 | 0.79 | HTR2A (0.50) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22033758 | 0.79 | HTR2A (0.55) | HTR2ARAB9ANPC1ALDH1A1TDP1 | |
| SCHEMBL7418355 | 0.79 | HTR2A (0.57) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6285251 | 0.78 | HTR2A (0.51) | HTR2ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14437515 | 0.78 | HTR2A (0.66) | HTR2ARAB9ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055450-A | Di-, tri- and tetrapeptides as inhibitors of human leukocyte elastase | ICI AMERICAS INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0189305-A2 | Peptide derivatives | ICI AMERICAS INC. (US) | 1986-07-30 | — | — | EP | disclosed |