Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8605623 | 0.87 | MAPT (0.52) | HTR2ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL28817737 | 0.86 | SLC1A3 (0.43) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29592309 | 0.84 | HTR2A (0.62) | HTR2ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL7417979 | 0.81 | POLB (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL7370462 | 0.81 | HTR2A (0.51) | HTR2ASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL1714950 | 0.80 | HTR2A (0.70) | HTR2ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2233881 | 0.80 | ALDH1A1 (0.49) | HTR2ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL11487784 | 0.80 | HTR2A (0.43) | HTR2ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL15459741 | 0.79 | HTR2A (0.53) | HTR2ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL7989561 | 0.79 | HTR2A (0.53) | HTR2ASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733882-A | Retroviral protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0602069-A4 | RETROVIRAL PROTEASE INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0602069-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-06-22 | — | — | EP | disclosed |
| WO-1993002057-A1 | RETROVIRAL PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-04 | — | — | WO | disclosed |