Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 20/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741965 | 1.00 | LTA4H (0.58) | LTA4HKCNH2EPHX2 | |
| SCHEMBL743492 | 0.88 | LTA4H (0.74) | LTA4HKCNH2EPHX2 | |
| SCHEMBL3754781 | 0.87 | LTA4H (0.57) | LTA4HKCNH2EPHX2 | |
| SCHEMBL3754776 | 0.87 | LTA4H (0.57) | LTA4HKCNH2EPHX2 | |
| SCHEMBL14093068 | 0.83 | LTA4H (0.73) | LTA4HKCNH2 | |
| SCHEMBL4693506 | 0.83 | LTA4H (0.73) | LTA4HKCNH2 | |
| SCHEMBL14093067 | 0.83 | LTA4H (0.73) | LTA4HKCNH2 | |
| SCHEMBL743395 | 0.83 | LTA4H (0.71) | LTA4HKCNH2EPHX2 | |
| SCHEMBL743903 | 0.82 | LTA4H (0.59) | LTA4HKCNH2EPHX2 | |
| SCHEMBL744056 | 0.82 | LTA4H (0.59) | LTA4HKCNH2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430019-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | Janssen Pharmaceutica, N.V. (BE) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132599-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-18 | — | — | WO | claimed |
| EP-2430019-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | Janssen Pharmaceutica, N.V. (BE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132599-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-18 | — | — | WO | disclosed |