Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512062 | 0.91 | CYP3A4 (0.64) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| SCHEMBL11134303 | 0.91 | CYP3A4 (0.64) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| SCHEMBL10594823 | 0.89 | CYP3A4 (0.65) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| SCHEMBL9302829 | 0.88 | CYP3A4 (0.64) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| SCHEMBL9597393 | 0.87 | CYP3A4 (0.78) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| Bromuconazole SCHEMBL3682832 | 0.86 | CYP3A4 (1.00) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| Bromuconazole SCHEMBL29360340 | 0.86 | CYP3A4 (1.00) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| SCHEMBL9597099 | 0.86 | CYP3A4 (0.77) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| Bromuconazole SCHEMBL22340 | 0.86 | CYP3A4 (1.00) | CYP3A4CYP2C9THRBKDM4ELMNA | |
| SCHEMBL10596297 | 0.85 | CYP3A4 (0.61) | CYP3A4CYP2C9THRBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0095828-B1 | ANTIFUNGAL TRIAZOLYL PROPANOL DERIVATIVES | Pfizer Limited (GB) | 1986-02-26 | — | — | EP | claimed |
| EP-0095828-A1 | Antifungal triazolyl propanol derivatives | Pfizer Limited (GB) | 1983-12-07 | — | — | EP | claimed |
| WO-2020122766-A1 | HYBRID AMIDES EXHIBITING ANTI-MICROBIAL ACTIVITY | ЛЕВШИН, Игорь Борисович | 2020-06-18 | — | — | WO | disclosed |
| US-20180194742-A1 | Antifungal Compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-07-12 | — | — | US | disclosed |
| US-20180194742-A1 | Antifungal Compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2018-07-12 | — | — | US | disclosed |
| EP-2337562-B1 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-07-24 | — | — | EP | disclosed |
| EP-2346861-B1 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-23 | — | — | EP | disclosed |
| US-8236840-B2 | Thiopene containing analogues of fluconazole as antifungal agents and process for their preparation | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-08-07 | — | — | US | disclosed |
| US-8129369-B2 | Antifungal compounds containing benzothiazinone, benzoxazinone or benzoxazolinone and process thereof | Council of Scientific & Industrial Research; (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110183968-A1 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-07-28 | — | — | US | disclosed |
| EP-2346861-A2 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | Council of Scientific and Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| EP-0115400-A1 | Triazole antifungal agents | Pfizer Limited (GB) | 1984-08-08 | — | — | EP | disclosed |
| EP-0113509-A2 | 1,3-Bis(triazolyl)-2-amino-2-aryl-propane derivatives and pharmaceutical fungicidal compositions containing them | Pfizer Limited (GB) | 1984-07-18 | — | — | EP | disclosed |
| EP-0111658-A2 | 1,3-Dihalopropan-2-ols | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-06-27 | — | — | EP | disclosed |
| EP-0107392-A1 | Triazole antifungal agents | Pfizer Limited (GB) | 1984-05-02 | — | — | EP | disclosed |
| EP-0106515-A2 | Triazole anti-fungal agents | Pfizer Limited (GB) | 1984-04-25 | — | — | EP | disclosed |
| EP-0095828-A1 | Antifungal triazolyl propanol derivatives | Pfizer Limited (GB) | 1983-12-07 | — | — | EP | disclosed |
| US-4416682-A | 1,3-Bis(azolyl)propanols as fungicides and plant growth regulators | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-11-22 | — | — | US | disclosed |
| EP-0091309-A2 | Triazole antifungal agents | Pfizer Limited (GB) | 1983-10-12 | — | — | EP | disclosed |
| EP-0044605-A1 | Fungicidal bis-azolyl compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-01-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194742-A1 | Antifungal Compounds | ERG28, DPM1, CYP51A1 | CYP3A4 431/4885CYP2C9 1058/4885THRB 4744/4885 |
| US-20110183968-A1 | ANTIFUNGAL COMPOUNDS CONTAINING BENZOTHIAZINONE, BENZOXAZINONE OR BENZOXAZOLINONE AND PROCESS THEREOF | CYP51A1, XPO1, XPO5 | CYP3A4 13/4885CYP2C9 37/4885THRB 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.